Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 9/20 | 0.76 |
| ▸ | MMP13 | P45452 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6463535 | 0.92 | MMP12 (0.88) | MMP12MMP13HDAC4HDAC6ABL1 | |
| SCHEMBL6881318 | 0.88 | MMP12 (0.82) | MMP12MMP13HDAC4HDAC6ABL1 | |
| SCHEMBL6451716 | 0.88 | MMP12 (0.81) | MMP12MMP13HDAC4HDAC6ABL1 | |
| SCHEMBL8337541 | 0.86 | MMP12 (0.76) | MMP12MMP13HDAC4HDAC6ABL1 | |
| SCHEMBL6369582 | 0.86 | MMP12 (1.00) | MMP12MMP13HDAC4HDAC6ABL1 | |
| SCHEMBL6879815 | 0.86 | MMP12 (1.00) | MMP12MMP13HDAC4HDAC6ABL1 | |
| SCHEMBL6882612 | 0.85 | MMP12 (0.82) | MMP12MMP13HDAC4HDAC6ABL1 | |
| SCHEMBL6882610 | 0.85 | MMP12 (0.82) | MMP12MMP13HDAC4HDAC6ABL1 | |
| SCHEMBL6370857 | 0.84 | MMP12 (0.78) | MMP12MMP13HDAC4HDAC6ABL1 | |
| SCHEMBL6370860 | 0.84 | MMP12 (0.78) | MMP12MMP13HDAC4HDAC6ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040072871-A1 | Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them | WARNER-LAMBERT COMPANY LLC | 2004-04-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072871-A1 | Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them | MMP11, MMP13, CBR1 | MMP12 7/4885MMP13 2/4885HDAC4 484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.