Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 12/20 | 0.54 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.54 |
| ▸ | F2 | P00734 | 3/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.54 |
| ▸ | PLG | P00747 | 1/20 | 0.54 |
| ▸ | PLAU | P00749 | 1/20 | 0.54 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.54 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.54 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.53 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.53 |
| ▸ | F7 | P08709 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9029139 | 0.87 | NISCH (0.54) | — | |
| SCHEMBL6879892 | 0.84 | NISCH (0.42) | F10F2F7 | |
| SCHEMBL6879930 | 0.83 | PRMT1 (0.41) | F10 | |
| SCHEMBL65730 | 0.82 | F10 (0.77) | F10TPSAB1F2PRSS1PLG | |
| SCHEMBL4322200 | 0.81 | TPSAB1 (0.78) | F10TPSAB1F2PRSS1PLG | |
| SCHEMBL9040777 | 0.80 | NISCH (0.47) | — | |
| SCHEMBL9111634 | 0.79 | NISCH (0.48) | — | |
| SCHEMBL14259704 | 0.77 | PRMT1 (0.53) | — | |
| SCHEMBL6163820 | 0.76 | F10 (0.85) | F10TPSAB1F2PRSS1PLG | |
| SCHEMBL7406105 | 0.76 | F10 (0.68) | F10TPSAB1F2PRSS1PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6815461-B1 | ADMINISTERING BIS-BENZIMIDAZOLE COMPOUND; TREATING HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2004-11-09 | — | — | US | disclosed |
| EP-0739202-A1 | USE OF BIS(AMIDINOBENZIMIDAZOLES) IN THE MANUFACTURE OF MEDICAMENT FOR INHIBITING RETROVIRAL INTEGRASE | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-10-30 | — | — | EP | disclosed |
| WO-1995019772-A1 | USE OF BIS(AMIDINOBENZIMIDAZOLES) IN THE MANUFACTURE OF MEDICAMENT FOR INHIBITING RETROVIRAL INTEGRASE | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1995-07-27 | — | — | WO | disclosed |