Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | DNM1L | O00429 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | BAZ2A | Q9UIF9 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044606 | 0.84 | HTR2A (0.44) | DNM1LCNR1HTR2AHTR2CSLC6A4 | |
| SCHEMBL6871844 | 0.84 | NOTUM (0.46) | NOTUMCNR1HTR2AHTR2CSLC6A4 | |
| SCHEMBL6879620 | 0.82 | NOTUM (0.44) | NOTUMALDH1A1 | |
| SCHEMBL6871896 | 0.81 | NOTUM (0.43) | NOTUMHTR2AHTR2CSLC6A4FEN1 | |
| SCHEMBL6872874 | 0.81 | NOTUM (0.42) | NOTUM | |
| SCHEMBL6879732 | 0.81 | NOTUM (0.42) | NOTUMCNR1HTR2AHTR2CSLC6A4 | |
| SCHEMBL6879641 | 0.81 | IDH1 (0.46) | NOTUMHTR2AHTR2CSLC6A4MEN1 | |
| SCHEMBL6878789 | 0.81 | NOTUM (0.42) | NOTUMCNR1HTR2AHTR2CSLC6A4 | |
| SCHEMBL5043491 | 0.80 | EIF4E (0.43) | NOTUMCNR1HTR2AHTR2CSLC6A4 | |
| SCHEMBL6884351 | 0.80 | MDM2 (0.46) | NOTUMHTR2AHTR2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | HOFFMAN-LA ROCHE INC. | 2004-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | CNR1, CNR2, NPY1R | NOTUM 1360/4885DNM1L 839/4885CNR1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.