Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TLR4 | O00206 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6881679 | 1.00 | BRD4 (0.39) | BRD4SMYD3ALDH1A1L3MBTL1POLB | |
| SCHEMBL6881684 | 1.00 | BRD4 (0.39) | BRD4SMYD3ALDH1A1L3MBTL1POLB | |
| SCHEMBL6638977 | 0.96 | BRD4 (0.39) | BRD4SMYD3ALDH1A1L3MBTL1POLB | |
| SCHEMBL6826955 | 0.83 | SMYD3 (0.39) | SMYD3ALDH1A1L3MBTL1POLBEPHX2 | |
| SCHEMBL6882324 | 0.83 | HPGD (0.41) | ALDH1A1EPHX2KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL6826953 | 0.83 | SMYD3 (0.39) | SMYD3ALDH1A1L3MBTL1POLBEPHX2 | |
| SCHEMBL6826951 | 0.83 | SMYD3 (0.39) | SMYD3ALDH1A1L3MBTL1POLBEPHX2 | |
| SCHEMBL6882320 | 0.83 | HPGD (0.41) | ALDH1A1EPHX2KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL6988937 | 0.83 | SMYD3 (0.39) | SMYD3ALDH1A1L3MBTL1POLBEPHX2 | |
| SCHEMBL6882316 | 0.83 | HPGD (0.41) | ALDH1A1EPHX2KMT2ATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040072871-A1 | Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them | WARNER-LAMBERT COMPANY LLC | 2004-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072871-A1 | Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them | MMP11, MMP13, CBR1 | BRD4 2719/4885SMYD3 4024/4885ALDH1A1 563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.