Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CTSA | P10619 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687488 | 0.93 | MAPT (0.51) | KDM4ESMN1; SMN2MAPTCTSAALDH1A1 | |
| SCHEMBL688082 | 0.92 | TP53 (0.41) | KDM4ESMN1; SMN2MAPTCTSAALDH1A1 | |
| SCHEMBL687925 | 0.89 | CYP26A1 (0.42) | KDM4ECTSAALDH1A1CYP26A1KEAP1 | |
| SCHEMBL687511 | 0.88 | MEN1 (0.46) | KDM4ESMN1; SMN2MAPTCTSAALDH1A1 | |
| SCHEMBL688110 | 0.86 | MEN1 (0.49) | KDM4EMAPTCTSAALDH1A1TP53 | |
| SCHEMBL687149 | 0.86 | CTSA (0.47) | MAPTCTSAALDH1A1CYP26A1PTGER3 | |
| SCHEMBL688084 | 0.86 | CYP26A1 (0.43) | KDM4EMAPTALDH1A1TP53CYP26A1 | |
| SCHEMBL686919 | 0.86 | GAA (0.45) | KDM4ESMN1; SMN2MAPTCTSAALDH1A1 | |
| SCHEMBL688357 | 0.85 | POLB (0.41) | KDM4EMAPTCTSAALDH1A1TP53 | |
| SCHEMBL687408 | 0.85 | KMT2A (0.43) | KDM4EHTTMAPTCTSAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |