Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 6/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 6/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687511 | 0.94 | MEN1 (0.46) | CYP26A1MEN1KMT2APOLBITGB1 | |
| SCHEMBL688082 | 0.92 | TP53 (0.41) | MEN1KMT2APOLBITGB1ITGA4 | |
| SCHEMBL687408 | 0.90 | KMT2A (0.43) | CYP26A1MEN1KMT2APOLBITGB1 | |
| SCHEMBL688110 | 0.90 | MEN1 (0.49) | CYP26A1MEN1KMT2APOLBITGB1 | |
| SCHEMBL686919 | 0.89 | GAA (0.45) | MEN1KMT2APOLBITGB1ITGA4 | |
| SCHEMBL688264 | 0.88 | LCK (0.47) | MEN1KMT2APOLBKEAP1NFE2L2 | |
| SCHEMBL687925 | 0.87 | CYP26A1 (0.42) | CYP26A1MEN1KMT2APOLBITGB1 | |
| SCHEMBL688413 | 0.87 | POLB (0.40) | CYP26A1MEN1KMT2APOLBITGB1 | |
| SCHEMBL688377 | 0.86 | LMNA (0.42) | MEN1KMT2APOLBITGB1ITGA4 | |
| SCHEMBL688202 | 0.86 | KDM4E (0.41) | CYP26A1MEN1KMT2APOLBITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |