Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CTSA | P10619 | 2/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EEF2K | O00418 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687511 | 0.93 | MEN1 (0.46) | TP53KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL688202 | 0.92 | KDM4E (0.41) | TP53KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL688084 | 0.92 | CYP26A1 (0.43) | TP53KDM4EALDH1A1UTS2RKMT2A | |
| SCHEMBL686919 | 0.90 | GAA (0.45) | KDM4EALDH1A1KMT2AMEN1POLB | |
| SCHEMBL687488 | 0.90 | MAPT (0.51) | TP53KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL687408 | 0.89 | KMT2A (0.43) | TP53KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL688110 | 0.89 | MEN1 (0.49) | TP53KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL688377 | 0.89 | LMNA (0.42) | TP53KMT2AMEN1POLBITGB1 | |
| SCHEMBL687149 | 0.88 | CTSA (0.47) | ALDH1A1UTS2RMAPTCTSAEEF2K | |
| SCHEMBL688264 | 0.87 | LCK (0.47) | KDM4EALDH1A1UTS2RKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |