Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 4/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.36 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8727224 | 0.82 | ALDH1A1 (0.35) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL8727131 | 0.77 | F2 (0.39) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL6882217 | 0.76 | F2 (0.37) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL6882223 | 0.76 | KDM4E (0.49) | F2PRSS1PRSS3ST14ALDH1A1 | |
| SCHEMBL8727096 | 0.76 | ROCK1 (0.46) | CA1CA2MAPK13MAPK12MAPK11 | |
| SCHEMBL8721634 | 0.76 | PRSS1 (0.50) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL8721646 | 0.75 | PIM1 (0.35) | F2PRSS1ST14CA1CA2 | |
| SCHEMBL8003077 | 0.74 | MAPT (0.54) | F2F7ALDH1A1HPGDAGTR1 | |
| SCHEMBL8723581 | 0.73 | ST14 (0.42) | ST14CA12CA1CA2CA9 | |
| SCHEMBL8721602 | 0.72 | MAPT (0.41) | F2PRSS1PRSS2PRSS3TMPRSS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832091-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040705-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA SICOR (US) | 1996-12-19 | — | — | WO | disclosed |