Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.69 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | TACR3 | P29371 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4278021 | 0.82 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDLMNAHSD17B10 | |
| SCHEMBL4278016 | 0.82 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDLMNAHSD17B10 | |
| SCHEMBL4290720 | 0.82 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDLMNAHSD17B10 | |
| SCHEMBL7023828 | 0.78 | CTSD (0.45) | ALDH1A1KDM4EPOLBL3MBTL1HDAC3 | |
| SCHEMBL14797294 | 0.76 | ALDH1A1 (0.67) | ALDH1A1KDM4EHPGDLMNAHSD17B10 | |
| SCHEMBL9953588 | 0.75 | POLB (0.75) | ALDH1A1KDM4EHPGDLMNAHSD17B10 | |
| SCHEMBL9953590 | 0.75 | POLB (0.75) | ALDH1A1KDM4EHPGDLMNAHSD17B10 | |
| SCHEMBL9953592 | 0.75 | POLB (0.75) | ALDH1A1KDM4EHPGDLMNAHSD17B10 | |
| SCHEMBL7431514 | 0.73 | ALDH1A1 (0.62) | ALDH1A1KDM4EHPGDLMNAHSD17B10 | |
| SCHEMBL7156234 | 0.73 | ALDH1A1 (0.62) | ALDH1A1KDM4EHPGDLMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004505014-A | — | — | 2004-02-19 | — | — | JP | claimed |
| EP-1268463-A2 | POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED 4-PYRONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | Pharmacia Corporation (US) | 2003-01-02 | — | — | EP | claimed |
| WO-2001077097-A2 | POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED 4-PYRONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-10-18 | — | — | WO | claimed |