Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 3/20 | 0.69 |
| ▸ | NOS3 | P29474 | 2/20 | 0.69 |
| ▸ | NOS1 | P29475 | 2/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.57 |
| ▸ | CYP2E1 | P05181 | 6/20 | 0.57 |
| ▸ | CYP2C8 | P10632 | 6/20 | 0.57 |
| ▸ | CYP2B6 | P20813 | 6/20 | 0.57 |
| ▸ | RAB9A | P51151 | 9/20 | 0.52 |
| ▸ | NPC1 | O15118 | 8/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6881221 | 0.91 | NOS2 (0.72) | NOS2NOS3NOS1CYP1A2CYP2D6 | |
| SCHEMBL6884539 | 0.88 | NOS2 (0.67) | NOS2NOS3NOS1CYP1A2CYP2D6 | |
| SCHEMBL6376330 | 0.85 | NOS2 (0.66) | NOS2NOS3NOS1CYP1A2CYP2D6 | |
| SCHEMBL6378263 | 0.84 | NOS2 (0.68) | NOS2NOS3NOS1CYP1A2CYP2D6 | |
| SCHEMBL10921495 | 0.81 | NOS2 (0.73) | NOS2NOS3NOS1CYP1A2CYP2D6 | |
| SCHEMBL2998260 | 0.81 | NOS2 (0.76) | NOS2NOS3NOS1CYP1A2CYP2D6 | |
| SCHEMBL6872792 | 0.81 | NPC1 (0.54) | NOS2NOS3NOS1CYP1A2CYP2D6 | |
| SCHEMBL10923700 | 0.80 | NOS2 (0.68) | NOS2NOS3NOS1CYP1A2CYP2D6 | |
| SCHEMBL10478420 | 0.80 | NOS2 (0.48) | NOS2NOS3NOS1CYP1A2CYP2D6 | |
| SCHEMBL8503495 | 0.80 | NOS2 (0.78) | NOS2NOS3NOS1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4628098-A | Including Prevacid (TM) lansoprazole, 2-(3-methyl-4-(2,2,2-trifluoroethoxy)-5-methyl-pyrid-2 -yl)methylsulfinylbenzimidazole; proton pump inhibitors, antiulcer, antisecretory agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1986-12-09 | — | — | US | claimed |
| US-20140328861-A1 | Combination of CRTH2 Antagonist and a Proton Pump Inhibitor for the Treatment of Eosinophilic Esophagitis | ATOPIX THERAPEUTICS LTD (GB) | 2014-11-06 | — | — | US | disclosed |
| EP-2790696-A1 | COMBINATION OF CRTH2 ANTAGONIST AND A PROTON PUMP INHIBITOR FOR THE TREATMENT OF EOSINOPHILIC ESOPHAGITIS | Atopix Therapeutics Limited (GB) | 2014-10-22 | — | — | EP | disclosed |
| WO-2013088109-A1 | COMBINATION OF CRTH2 ANTAGONIST AND A PROTON PUMP INHIBITOR FOR THE TREATMENT OF EOSINOPHILIC ESOPHAGITIS | OXAGEN LIMITED (GB) | 2013-06-20 | — | — | WO | disclosed |
| US-20040258621-A1 | Method of treating snoring and other obstructive breathing disorders | SOHNSTEARNS & STERN | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040258621-A1 | Method of treating snoring and other obstructive breathing disorders | HRH2, HRH1, HRH4 | NOS2 424/4885NOS3 426/4885NOS1 362/4885 |
| US-20140328861-A1 | Combination of CRTH2 Antagonist and a Proton Pump Inhibitor for the Treatment of Eosinophilic Esophagitis | HRH2, HRH1, HRH4 | NOS2 3162/4885NOS3 3784/4885NOS1 4105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.