Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 3/20 | 0.78 |
| ▸ | NOS3 | P29474 | 2/20 | 0.78 |
| ▸ | NOS1 | P29475 | 2/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.58 |
| ▸ | CYP2E1 | P05181 | 5/20 | 0.58 |
| ▸ | CYP2C8 | P10632 | 5/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.58 |
| ▸ | CYP2B6 | P20813 | 5/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | GALR3 | O60755 | 1/20 | 0.54 |
| ▸ | STAT3 | P40763 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8503548 | 0.98 | NOS2 (0.78) | NOS2NOS3NOS1CYP1A2CYP2E1 | |
| SCHEMBL6378263 | 0.85 | NOS2 (0.68) | NOS2NOS3NOS1CYP1A2CYP2E1 | |
| SCHEMBL2998260 | 0.83 | NOS2 (0.76) | NOS2NOS3NOS1CYP1A2CYP2E1 | |
| SCHEMBL10921495 | 0.82 | NOS2 (0.73) | NOS2NOS3NOS1CYP1A2CYP2E1 | |
| SCHEMBL6881221 | 0.81 | NOS2 (0.72) | NOS2NOS3NOS1CYP1A2CYP2E1 | |
| SCHEMBL6376330 | 0.81 | NOS2 (0.66) | NOS2NOS3NOS1CYP1A2CYP2E1 | |
| SCHEMBL8500232 | 0.81 | NOS3 (0.56) | NOS2NOS3NOS1CYP1A2CYP2E1 | |
| SCHEMBL6882863 | 0.80 | NOS2 (0.69) | NOS2NOS3NOS1CYP1A2CYP2E1 | |
| SCHEMBL10923700 | 0.79 | NOS2 (0.68) | NOS2NOS3NOS1CYP1A2CYP2E1 | |
| SCHEMBL6884539 | 0.78 | NOS2 (0.67) | NOS2NOS3NOS1CYP1A2CYP2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998445-A | PEPTIC ULCERS | EISAI CO., LTD. (JP) | 1999-12-07 | — | — | US | disclosed |
| EP-0786461-A1 | Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and a process for preparing the same | Eisai Co., Ltd. (JP) | 1997-07-30 | — | — | EP | disclosed |
| EP-0654471-A1 | Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and process for preparing the same | Eisai Co., Ltd. (JP) | 1995-05-24 | — | — | EP | disclosed |
| EP-0475456-A1 | Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and a process for preparing the same | Eisai Co., Ltd. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-5045552-A | Pyridine derivatives having anti-ulcerative activity | EISAI CO., LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0268956-A2 | Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and a process for preparing the same | Eisai Co., Ltd. (JP) | 1988-06-01 | — | — | EP | disclosed |