Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 6/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | F3 | P13726 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6882901 | 1.00 | METAP2 (0.53) | METAP2HTTTRPM8F3RAB9A | |
| SCHEMBL6885651 | 0.88 | METAP2 (0.49) | METAP2TRPM8RAB9AMEN1MAPT | |
| SCHEMBL6884374 | 0.81 | METAP2 (0.47) | METAP2HTTTRPM8F3RAB9A | |
| SCHEMBL6886678 | 0.81 | METAP2 (0.49) | METAP2HTTTRPM8RAB9AMEN1 | |
| SCHEMBL6886738 | 0.81 | METAP2 (0.47) | METAP2HTTTRPM8F3RAB9A | |
| SCHEMBL6886683 | 0.81 | METAP2 (0.49) | METAP2HTTTRPM8RAB9AMEN1 | |
| SCHEMBL23710407 | 0.80 | METAP2 (0.81) | METAP2MEN1MAPTKMT2AABCB11 | |
| SCHEMBL6883789 | 0.80 | METAP2 (0.81) | METAP2MEN1MAPTKMT2AABCB11 | |
| SCHEMBL21582882 | 0.80 | METAP2 (0.81) | METAP2MEN1MAPTKMT2AABCB11 | |
| SCHEMBL19254377 | 0.80 | METAP2 (0.57) | METAP2HTTRAB9AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6803382-B2 | 1-OXASPIRO(2,5)OCTAN-6-OL DERIVATIVES | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2004-10-12 | — | — | US | claimed |
| US-6803382-B2 | 1-OXASPIRO(2,5)OCTAN-6-OL DERIVATIVES | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2004-10-12 | — | — | US | disclosed |