Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 3/20 | 0.44 |
| ▸ | AGXT | P21549 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | APLNR | P35414 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6550926 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1TP53CYP3A4ALOX15 | |
| SCHEMBL16594094 | 0.78 | IDO1 (0.48) | SMN1; SMN2ALDH1A1TP53CYP3A4ALOX15 | |
| SCHEMBL7069810 | 0.78 | IDO1 (0.48) | SMN1; SMN2ALDH1A1TP53CYP3A4ALOX15 | |
| SCHEMBL17616786 | 0.77 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1TP53CYP3A4ALOX15 | |
| SCHEMBL12502485 | 0.75 | IDO1 (0.53) | SMN1; SMN2IDO1AGXTNPC1RAB9A | |
| SCHEMBL14567491 | 0.75 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1TP53CYP3A4ALOX15 | |
| SCHEMBL14567490 | 0.75 | NPC1 (0.47) | SMN1; SMN2ALDH1A1TP53CYP3A4ALOX15 | |
| SCHEMBL2692649 | 0.75 | IDO1 (0.42) | SMN1; SMN2ALDH1A1TP53CYP3A4ALOX15 | |
| SCHEMBL936399 | 0.73 | IDO1 (0.55) | IDO1AGXTAPPMAOBCA1 | |
| SCHEMBL17900959 | 0.73 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1TP53CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6803382-B2 | 1-OXASPIRO(2,5)OCTAN-6-OL DERIVATIVES | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2004-10-12 | — | — | US | disclosed |
| US-20030134896-A1 | Novel angiogenesis inhibitors and pharmaceutical and cosmetic use thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2003-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030134896-A1 | Novel angiogenesis inhibitors and pharmaceutical and cosmetic use thereof | VEGFA, KDR, FLT1 | SMN1; SMN2 4306/4885ALDH1A1 113/4885TP53 1723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.