Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 13/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687304 | 0.89 | KEAP1 (0.41) | CTSAKEAP1NFE2L2CYP26A1LMNA | |
| SCHEMBL687342 | 0.86 | CTSA (0.41) | POLBCTSA | |
| SCHEMBL687472 | 0.86 | KMT2A (0.41) | POLBCTSAKEAP1NFE2L2CYP26A1 | |
| SCHEMBL688301 | 0.84 | PTGER4 (0.42) | CTSA | |
| SCHEMBL687670 | 0.83 | ITGB1 (0.38) | CTSAKEAP1NFE2L2CYP26A1LMNA | |
| SCHEMBL687499 | 0.83 | CTSA (0.45) | POLBCTSA | |
| SCHEMBL687706 | 0.83 | CTSA (0.45) | CTSA | |
| SCHEMBL688046 | 0.82 | CTSA (0.42) | CTSAKEAP1NFE2L2CYP26A1 | |
| SCHEMBL688251 | 0.82 | CTSA (0.44) | CTSACYP26A1 | |
| SCHEMBL688871 | 0.81 | CTSA (0.44) | CTSACYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |