Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.47 |
| ▸ | VDR | P11473 | 7/20 | 0.34 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.31 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.31 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.30 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6156152 | 1.00 | HMGCR (0.47) | HMGCRVDRCYP24A1CYP4F2CYP4A11 | |
| SCHEMBL6885094 | 0.84 | CYP4F2 (0.42) | HMGCRCYP4F2CYP4A11HDAC4MEF2D | |
| SCHEMBL6885108 | 0.84 | CYP4F2 (0.42) | HMGCRCYP4F2CYP4A11HDAC4MEF2D | |
| SCHEMBL6881439 | 0.79 | HMGCR (0.35) | HMGCR | |
| SCHEMBL2106866 | 0.79 | HMGCR (0.55) | HMGCRVDRCYP24A1CYP4F2CYP4A11 | |
| SCHEMBL2107875 | 0.78 | HMGCR (0.57) | HMGCRVDRCYP24A1AKR1B10AKR1B1 | |
| SCHEMBL2107876 | 0.78 | HMGCR (0.57) | HMGCRVDRCYP24A1AKR1B10AKR1B1 | |
| SCHEMBL6154939 | 0.78 | HMGCR (0.54) | HMGCRVDRCYP24A1CYP4F2CYP4A11 | |
| SCHEMBL2106842 | 0.77 | HMGCR (0.56) | HMGCRVDRCYP24A1AKR1B10AKR1B1 | |
| SCHEMBL2106841 | 0.77 | HMGCR (0.56) | HMGCRVDRCYP24A1AKR1B10AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689922-B1 | BIAROMATIC COMPOUNDS WHICH ARE ANALOGUES OF VITAMIN D HAVE A MARKED ACTIVITY IN THE FIELDS OF CELL DIFFERENTIATION AND PROLIFERATION | GALDERMA RESEARCH & DEVELOPMENT S.N.C. (FR) | 2004-02-10 | — | — | US | disclosed |