Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 8/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14184929 | 0.71 | HCAR2 (0.42) | HCAR2DAOKMT2ATSHR | |
| SCHEMBL38653255 | 0.70 | PDE2A (0.52) | ALDH1A1HCAR2POLBKDM4E | |
| SCHEMBL4704331 | 0.67 | HCAR2 (0.37) | HCAR2DAOKMT2A | |
| SCHEMBL19698918 | 0.67 | ALDH1A1 (0.42) | ALDH1A1MAPK1SMN1; SMN2DAOKMT2A | |
| SCHEMBL15058237 | 0.66 | SMN1; SMN2 (0.48) | ALDH1A1MAPK1SMN1; SMN2HCAR2KMT2A | |
| SCHEMBL27037937 | 0.66 | HCAR2 (0.46) | HCAR2DAOKMT2AKDM4ETSHR | |
| SCHEMBL16235687 | 0.66 | MCL1 (0.46) | SMN1; SMN2HCAR2KMT2AKDM4E | |
| SCHEMBL22169259 | 0.66 | SMN1; SMN2 (0.44) | ALDH1A1MAPK1SMN1; SMN2HCAR2KMT2A | |
| SCHEMBL20488921 | 0.65 | PRKAG1 (0.39) | HCAR2 | |
| SCHEMBL13632234 | 0.65 | PRKAG1 (0.53) | HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082079-A1 | Low affinity screening method | GRAFFINITY PHARMACEUTICALS AG. (DE) | 2004-04-29 | — | — | US | disclosed |
| EP-1360489-A1 | LOW AFFINITY SCREENING METHOD | Graffinity Pharmaceuticals Aktiengesellschaft (DE) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002063299-A1 | LOW AFFINITY SCREENING METHOD | GRAFFINITY PHARMACEUTICALS AG (DE) | 2002-08-15 | — | — | WO | disclosed |