Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.73 |
| ▸ | RAB9A | P51151 | 2/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12301768 | 0.89 | LMNA (0.75) | LMNANPSR1RAB9ASMN1; SMN2HTT | |
| SCHEMBL12892245 | 0.86 | LMNA (0.71) | LMNANPSR1RAB9ASMN1; SMN2HTT | |
| SCHEMBL11985505 | 0.84 | LMNA (0.69) | LMNANPSR1RAB9ASMN1; SMN2HTT | |
| SCHEMBL3354341 | 0.83 | HSD17B10 (0.65) | LMNANPSR1RAB9ASMN1; SMN2ALOX15 | |
| SCHEMBL23915567 | 0.81 | LMNA (0.64) | LMNANPSR1RAB9ASMN1; SMN2HTT | |
| SCHEMBL12877767 | 0.81 | LMNA (0.64) | LMNANPSR1RAB9ASMN1; SMN2HTT | |
| SCHEMBL24076967 | 0.81 | ALOX15 (1.00) | LMNANPSR1RAB9AALOX15TSHR | |
| SCHEMBL24000166 | 0.80 | ALDH1A1 (0.65) | LMNANPSR1RAB9ASMN1; SMN2HTT | |
| SCHEMBL13799881 | 0.79 | ALOX15 (1.00) | NPSR1RAB9ASMN1; SMN2ALOX15TSHR | |
| SCHEMBL31703144 | 0.79 | ALOX15 (1.00) | NPSR1RAB9ASMN1; SMN2ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082079-A1 | Low affinity screening method | GRAFFINITY PHARMACEUTICALS AG. (DE) | 2004-04-29 | — | — | US | disclosed |
| EP-1360489-A1 | LOW AFFINITY SCREENING METHOD | Graffinity Pharmaceuticals Aktiengesellschaft (DE) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002063299-A1 | LOW AFFINITY SCREENING METHOD | GRAFFINITY PHARMACEUTICALS AG (DE) | 2002-08-15 | — | — | WO | disclosed |