Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5815276 | 0.89 | KCNH2 (0.48) | DRD2DRD4ACHE | |
| SCHEMBL5781339 | 0.89 | MAOA (0.48) | ACHE | |
| SCHEMBL5778111 | 0.85 | KCNH2 (0.50) | DRD2DRD4 | |
| SCHEMBL5779581 | 0.85 | DRD2 (0.55) | DRD2DRD4DRD3ACHE | |
| SCHEMBL5780528 | 0.85 | KCNH2 (0.45) | — | |
| SCHEMBL6896303 | 0.84 | KCNH2 (0.44) | — | |
| SCHEMBL5781481 | 0.84 | KCNH2 (0.44) | — | |
| SCHEMBL6886679 | 0.82 | MCHR1 (0.38) | DRD2DRD4 | |
| SCHEMBL5780194 | 0.79 | DRD2 (0.61) | DRD2DRD4DRD3ACHE | |
| SCHEMBL5781775 | 0.78 | DRD2 (0.45) | DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6784192-B2 | NA+ CHANNEL INHIBITORY ACTION IS USEFUL FOR THERAPY AND PREVENTION FOR EXAMPLE, ARRHYTHMIA, VARIOUS NEURALGIAS AND ANALGESIC | EISAI CO., LTD. (JP) | 2004-08-31 | — | — | US | disclosed |
| EP-1254904-A1 | NOVEL PIPERIDINE COMPOUNDS AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-11-06 | — | — | EP | disclosed |