Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 5/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8680907 | 0.81 | EPHX1 (0.53) | SMN1; SMN2ACHEOPRM1OPRD1OPRK1 | |
| SCHEMBL3905171 | 0.79 | SMN1; SMN2 (0.38) | SMN1; SMN2CYP2D6CHRNB2CHRNA5CHRNA7 | |
| SCHEMBL688825 | 0.79 | SMN1; SMN2 (0.38) | SMN1; SMN2CYP2D6CHRNB2CHRNA5CHRNA7 | |
| SCHEMBL688697 | 0.79 | SMN1; SMN2 (0.38) | SMN1; SMN2CYP2D6CHRNB2CHRNA5CHRNA7 | |
| SCHEMBL8680813 | 0.77 | ALDH1A1 (0.48) | CHRM1SMN1; SMN2ACHECYP2D6CHRM3 | |
| SCHEMBL8704065 | 0.77 | SMN1; SMN2 (0.37) | SMN1; SMN2CYP2D6CHRNB2CHRNA5CHRNA7 | |
| Hydrochloric Acid SCHEMBL21801417 | 0.77 | SMN1; SMN2 (0.40) | CHRM1SMN1; SMN2CYP2D6CHRM3 | |
| SCHEMBL8683160 | 0.74 | SMN1; SMN2 (0.35) | CHRM1SMN1; SMN2BCHECHRNB2CHRNA5 | |
| SCHEMBL9330153 | 0.74 | EPHX1 (0.38) | OPRM1BCHECHRNB2CHRNA4 | |
| SCHEMBL6695503 | 0.73 | CHRM2 (0.39) | CHRM1CYP2D6CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843983-A | Diphenylethane compounds containing a saturated heterocyclic group, their preparation, and their therapeutic use | SANKYO COMPANY, LIMITED (JP) | 1998-12-01 | — | — | US | disclosed |
| EP-0844000-A1 | Use of alpha, omega-diarylalkane derivatives in the treatment and prevention of psychosis | SANKYO COMPANY LIMITED (JP) | 1998-05-27 | — | — | EP | disclosed |
| US-5556864-A | TREATMENT OF CIRCULATORY DISEASES AND PSYCHOSIS | SANKYO COMPANY, LIMITED (JP) | 1996-09-17 | — | — | US | disclosed |
| EP-0600717-A1 | Phenoxyalkylamines, -pyrrolidines and -piperidines for the treatment and prevention of circulatory diseases and psychosis | SANKYO COMPANY LIMITED (JP) | 1994-06-08 | — | — | EP | disclosed |