SCHEMBL6887329

SCHEMBL6887329

COc1cc(/C=C2\SC(=S)N(CC(=O)O)C2=O)cc(OC)c1O

nearest known ligand 0.71

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 6/20 0.71
▸ KMT2A Q03164 6/20 0.71
▸ POLB P06746 3/20 0.71
▸ PSMD14 O00487 1/20 0.71
▸ AKR1B1 P15121 4/20 0.68
▸ PTPN1 P18031 1/20 0.66
▸ PDE4B Q07343 1/20 0.64
▸ MAPT P10636 2/20 0.61
▸ ALDH1A1 P00352 1/20 0.61
▸ LMNA P02545 1/20 0.61
▸ GAA P10253 1/20 0.61
▸ GFER P55789 2/20 0.61
▸ CASP6 P55212 1/20 0.61
▸ NPC1 O15118 1/20 0.61
▸ MAPK1 P28482 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6887336 1.00 MEN1 (0.71) MEN1KMT2APOLBPSMD14AKR1B1
SCHEMBL17779690 0.93 AKR1B1 (0.63) MEN1KMT2APOLBPSMD14AKR1B1
SCHEMBL20837934 0.93 AKR1B1 (0.63) MEN1KMT2APOLBPSMD14AKR1B1
SCHEMBL20837903 0.92 MEN1 (0.75) MEN1KMT2APOLBPSMD14AKR1B1
SCHEMBL17779681 0.92 MEN1 (0.75) MEN1KMT2APOLBPSMD14AKR1B1
SCHEMBL31284000 0.89 PTPN1 (0.61) MEN1KMT2APOLBPSMD14AKR1B1
SCHEMBL18102843 0.89 AKR1B1 (0.58) MEN1KMT2APOLBPSMD14AKR1B1
SCHEMBL31283784 0.89 PTPN1 (0.61) MEN1KMT2APOLBPSMD14AKR1B1
SCHEMBL12008449 0.89 TAS2R14 (0.76) MEN1KMT2APOLBPSMD14MAPT
SCHEMBL9393527 0.88 PDE4B (0.78) MEN1KMT2APOLBAKR1B1PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12590127-B2 Split photoactive yellow protein complementation system and uses thereof PARIS SCIENCES ET LETTRES (FR) 2026-03-31 — — US claimed
US-20220169682-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF PARIS SCIENCES ET LETTRES (FR) 2022-06-02 — — US claimed
EP-3947355-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF Paris Sciences et Lettres (FR) 2022-02-09 — — EP claimed
WO-2020201538-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF PARIS SCIENCES ET LETTRES – QUARTIER LATIN (FR) 2020-10-08 — — WO claimed
EP-3719007-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF Paris Sciences et Lettres - Quartier Latin (FR) 2020-10-07 — — EP claimed
US-12590127-B2 Split photoactive yellow protein complementation system and uses thereof PARIS SCIENCES ET LETTRES (FR) 2026-03-31 — — US disclosed
EP-4584590-A1 PROXIMITY INDUCING SYSTEM AND USES THEREOF SORBONNE UNIVERSITE (FR) 2025-07-16 — — EP disclosed
WO-2024052353-A1 PROXIMITY INDUCING SYSTEM AND USES THEREOF SORBONNE UNIVERSITE (FR) 2024-03-14 — — WO disclosed
US-20220169682-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF PARIS SCIENCES ET LETTRES (FR) 2022-06-02 — — US disclosed
EP-3947355-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF Paris Sciences et Lettres (FR) 2022-02-09 — — EP disclosed
US-11162951-B2 Membrane-impermeant fluorogenic chromophores PARIS SCIENCES ET LETTRES (FR) 2021-11-02 — — US disclosed
US-11162951-B2 Membrane-impermeant fluorogenic chromophores PARIS SCIENCES ET LETTRES (FR) 2021-11-02 — — US disclosed
EP-3719007-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF Paris Sciences et Lettres - Quartier Latin (FR) 2020-10-07 — — EP disclosed
EP-3404022-B1 MEMBRANE-IMPERMEANT FLUOROGENIC CHROMOPHORES PARIS SCIENCES LETTRES QUARTIER LATIN (FR) 2020-10-07 — — EP disclosed
US-20200124611-A1 MEMBRANE-IMPERMEANT FLUOROGENIC CHROMOPHORES PARIS SCIENCES ET LETTRES - QUARTIER LATIN (FR) 2020-04-23 — — US disclosed
US-20200124611-A1 MEMBRANE-IMPERMEANT FLUOROGENIC CHROMOPHORES PARIS SCIENCES ET LETTRES - QUARTIER LATIN (FR) 2020-04-23 — — US disclosed
WO-2018211090-A1 MEMBRANE-IMPERMEABLE FLUOROGENIC CHROMOPHORES PARIS SCIENCES ET LETTRES - QUARTIER LATIN (FR) 2018-11-22 — — WO disclosed
EP-3404022-A1 MEMBRANE-IMPERMEABLE FLUOROGENIC CHROMOPHORES Paris Sciences et Lettres - Quartier Latin (FR) 2018-11-21 — — EP disclosed
US-6673816-B1 Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders Esswein, Angelika (DE) 2004-01-06 — — US disclosed
US-20030032813-A1 Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders ANGELIKA ESSWEIN, WOLFGANG SCHAEFER, AND KONRAD HONOLD 2003-02-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200124611-A1 MEMBRANE-IMPERMEANT FLUOROGENIC CHROMOPHORES QRFPR, BLVRB, IK MEN1 3340/4885KMT2A 2506/4885POLB 3419/4885
US-20220169682-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF BLVRB, IK, HBG2 MEN1 3845/4885KMT2A 1217/4885POLB 1720/4885
US-20030032813-A1 Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders NR1H4, NR1D1, NR1I2 MEN1 838/4885KMT2A 1995/4885POLB 2514/4885
US-11162951-B2 Membrane-impermeant fluorogenic chromophores QRFPR, BLVRB, IK MEN1 3340/4885KMT2A 2506/4885POLB 3419/4885
US-12590127-B2 Split photoactive yellow protein complementation system and uses thereof BLVRB, HBG2, Q6ZSR9 MEN1 3100/4885KMT2A 1218/4885POLB 1574/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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