Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.32 |
| ▸ | P2RY2 | P41231 | 7/20 | 0.60 |
| ▸ | P2RY4 | P51582 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.33 |
| ▸ | RAB9A | P51151 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6887907 | 0.80 | P2RY2 (0.83) | P2RY2P2RY4 | |
| Phosphoric Acid SCHEMBL6393352 | 0.80 | P2RY2 (0.59) | P2RY2P2RY4NPC1RAB9AMAPT | |
| Phosphoric Acid SCHEMBL6886618 | 0.76 | P2RY2 (0.59) | P2RY2P2RY4ALDH1A1GAA | |
| Phosphoric Acid SCHEMBL6394309 | 0.75 | P2RY2 (0.56) | P2RY2P2RY4NPC1RAB9ALMNA | |
| SCHEMBL6888217 | 0.72 | P2RY2 (0.53) | P2RY2NPC1RAB9ALMNAMAPT | |
| Phosphoric Acid SCHEMBL6400578 | 0.69 | P2RY2 (0.63) | P2RY2NPC1RAB9ALMNAMAPT | |
| SCHEMBL23290946 | 0.66 | ALDH1A1 (0.43) | P2RY2P2RY4NPC1RAB9ALMNA | |
| SCHEMBL6393348 | 0.60 | P2RY2 (0.82) | P2RY2P2RY4NPC1RAB9AMAPT | |
| SCHEMBL20554157 | 0.56 | NR1H4 (0.39) | LMNAGAA | |
| SCHEMBL20554184 | 0.55 | SMN1; SMN2 (0.51) | NPC1RAB9ALMNAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1409503-A1 | NON-NATURAL CARBON-LINKED NUCLEOTIDES AND DINUCLEOTIDES | Celltech R & D Limited (GB) | 2004-04-21 | — | — | EP | claimed |
| WO-2003011885-A1 | NON-NATURAL CARBON-LINKED NUCLEOTIDES AND DINUCLEOTIDES | CELLTECH R & D LIMITED (GB) | 2003-02-13 | — | — | WO | claimed |
| EP-1409503-A1 | NON-NATURAL CARBON-LINKED NUCLEOTIDES AND DINUCLEOTIDES | Celltech R & D Limited (GB) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003011885-A1 | NON-NATURAL CARBON-LINKED NUCLEOTIDES AND DINUCLEOTIDES | CELLTECH R & D LIMITED (GB) | 2003-02-13 | — | — | WO | disclosed |