Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 7/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | PKM | P14618 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6888532 | 0.83 | MAPT (0.37) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6887943 | 0.81 | RAB9A (0.38) | NPC1RAB9APKMALDH1A1TP53 | |
| SCHEMBL6884593 | 0.78 | NPC1 (0.44) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL6883829 | 0.77 | PTPN1 (0.44) | GRM4NPC1RAB9AALDH1A1JAK1 | |
| SCHEMBL6887196 | 0.76 | MAPT (0.37) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6881846 | 0.75 | BACE1 (0.45) | NPC1RAB9APKMALDH1A1SMN1; SMN2 | |
| SCHEMBL6027185 | 0.74 | PTPN1 (0.44) | GRM4NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL6030750 | 0.73 | RAB9A (0.62) | GRM4NPC1RAB9APKMALDH1A1 | |
| SCHEMBL14182988 | 0.73 | GRM4 (0.41) | GRM4NPC1RAB9APKMALDH1A1 | |
| SCHEMBL14182964 | 0.73 | GRM4 (0.41) | GRM4NPC1RAB9APKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040229927-A1 | Imidazole derivatives for treatment of allergic and hyperproliferative disorders | AVANIR PHARMACEUTICALS | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229927-A1 | Imidazole derivatives for treatment of allergic and hyperproliferative disorders | ICOS, TSLP, IKZF3 | ITGA4 1992/4885GRM4 4630/4885NPC1 4755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.