Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11742871 | 0.85 | OPRM1 (0.56) | OPRM1OPRD1OPRK1CHRNA7DRD4 | |
| SCHEMBL6888881 | 0.82 | HSD11B1 (0.50) | OPRM1OPRD1OPRK1 | |
| SCHEMBL27602713 | 0.81 | DRD4 (0.39) | OPRM1DRD4 | |
| SCHEMBL2476831 | 0.80 | OPRL1 (0.65) | OPRM1 | |
| SCHEMBL10819383 | 0.79 | OPRM1 (0.58) | OPRM1OPRD1OPRK1CHRNA7 | |
| Hydrochloric Acid SCHEMBL6543403 | 0.79 | POLB (0.66) | OPRM1 | |
| SCHEMBL16565878 | 0.79 | MAOA (0.63) | OPRM1OPRD1OPRK1CHRNA7 | |
| SCHEMBL56772 | 0.79 | OPRM1 (0.60) | OPRM1OPRD1OPRK1DRD4 | |
| SCHEMBL6925016 | 0.78 | OPRM1 (0.53) | OPRM1OPRD1OPRK1CHRNA7DRD4 | |
| SCHEMBL8213555 | 0.78 | OPRL1 (0.67) | OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011062853-A1 | QUINOLIZIDINONE CARBOXAMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-05-26 | — | — | WO | disclosed |