Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 6/20 | 0.50 |
| ▸ | CA2 | P00918 | 6/20 | 0.50 |
| ▸ | CA12 | O43570 | 5/20 | 0.50 |
| ▸ | CA9 | Q16790 | 5/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.50 |
| ▸ | CA7 | P43166 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KDM4A | O75164 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.48 |
| ▸ | PTPRC | P08575 | 1/20 | 0.48 |
| ▸ | PTPRF | P10586 | 1/20 | 0.48 |
| ▸ | CDC25B | P30305 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29141105 | 0.85 | EGFR (0.59) | EGFRCA1CA2CA12CA9 | |
| SCHEMBL2035147 | 0.85 | EGFR (0.71) | EGFRCA1CA2CA12CA9 | |
| SCHEMBL2038076 | 0.83 | EGFR (0.49) | EGFRCA1CA2CA12CA9 | |
| SCHEMBL29788171 | 0.83 | EGFR (0.49) | EGFRCA1CA2CA12CA9 | |
| SCHEMBL6566323 | 0.81 | RXRA (0.46) | EGFRCA1CA2CA12CA9 | |
| SCHEMBL6882126 | 0.80 | CA12 (0.50) | EGFRCA1CA2CA12CA9 | |
| SCHEMBL6887241 | 0.78 | PDK2 (0.49) | EGFRCA1CA2CA12CA9 | |
| SCHEMBL3312749 | 0.78 | EGFR (0.58) | EGFRCA1CA2CA12CA9 | |
| SCHEMBL27708108 | 0.78 | EGFR (0.71) | EGFRCA1CA2CA12CA9 | |
| SCHEMBL2037520 | 0.77 | NR3C1 (0.57) | EGFRCA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6831106-B1 | Selective activity on cell proliferation and differentiation without displaying any hypercalcaemiant nature | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2004-12-14 | — | — | US | disclosed |