Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | KLK7 | P49862 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CNR1 | P21554 | 3/20 | 0.52 |
| ▸ | CNR2 | P34972 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HPGDS | O60760 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12802892 | 0.87 | CHRM1 (0.53) | MAPT | |
| SCHEMBL6892258 | 0.87 | GAA (0.56) | MAPTALDH1A1CNR1CNR2RAB9A | |
| SCHEMBL6890001 | 0.83 | SMN1; SMN2 (0.51) | MAPTALDH1A1CNR1CNR2RAB9A | |
| SCHEMBL6892450 | 0.83 | CHRM1 (0.54) | MAPTALDH1A1RAB9ASMN1; SMN2GAA | |
| SCHEMBL22212632 | 0.83 | CHRM1 (0.61) | RAB9ANPC1EPHX2SMN1; SMN2 | |
| SCHEMBL6892513 | 0.81 | CHRM1 (0.64) | RAB9A | |
| SCHEMBL2224496 | 0.81 | GAA (0.55) | MAPTALDH1A1CNR1RAB9ASMN1; SMN2 | |
| SCHEMBL6890115 | 0.81 | GAA (0.45) | MAPTALDH1A1CNR1CNR2RAB9A | |
| SCHEMBL6890076 | 0.81 | KCNH2 (0.48) | MAPTALDH1A1RAB9ASMN1; SMN2GAA | |
| SCHEMBL6891970 | 0.81 | GAA (0.49) | MAPTALDH1A1RAB9ASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084368-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |