Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 6/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.44 |
| ▸ | KLK1 | P06870 | 2/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.38 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6896588 | 0.93 | PLA2G2A (0.44) | PLA2G2APLA2G1BKLK1KLKB1AR | |
| SCHEMBL6689196 | 0.93 | GAA (0.47) | PLA2G2APLA2G1BARMAPTALDH1A1 | |
| SCHEMBL6897627 | 0.91 | PLA2G2A (0.46) | PLA2G2APLA2G1BKLK1KLKB1AR | |
| SCHEMBL6897303 | 0.90 | PLA2G2A (0.42) | PLA2G2APLA2G1BKLK1KLKB1AR | |
| SCHEMBL6894729 | 0.90 | MAPT (0.41) | PLA2G2AMAPTALDH1A1GAAPKM | |
| SCHEMBL6885056 | 0.90 | MAPT (0.46) | PLA2G2APLA2G1BARMAPTALDH1A1 | |
| SCHEMBL6691521 | 0.90 | MAPT (0.49) | MAPTALDH1A1GAAPKMTHRB | |
| SCHEMBL6694644 | 0.89 | AR (0.45) | PLA2G2AARMAPTALDH1A1GAA | |
| SCHEMBL6896220 | 0.88 | FAAH (0.43) | MAPTALDH1A1GAAPKMTHRB | |
| SCHEMBL6776997 | 0.88 | PLA2G2A (0.48) | PLA2G2APLA2G1BKLK1KLKB1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |