Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 6/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.41 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6889571 | 0.93 | PLA2G2A (0.44) | GAAMAPTALDH1A1PKMPLA2G2A | |
| SCHEMBL6894729 | 0.93 | MAPT (0.41) | GAAMAPTALDH1A1PKMPLA2G2A | |
| SCHEMBL6691521 | 0.92 | MAPT (0.49) | GAAMAPTALDH1A1PKMNPSR1 | |
| SCHEMBL6889588 | 0.92 | PLA2G2A (0.49) | GAAMAPTALDH1A1PKMPLA2G2A | |
| SCHEMBL6896220 | 0.91 | FAAH (0.43) | GAAMAPTALDH1A1PKMTHRB | |
| SCHEMBL6888834 | 0.91 | HSP90AA1 (0.41) | GAAMAPTALDH1A1PKMPLA2G2A | |
| SCHEMBL6688534 | 0.89 | MAPT (0.45) | GAAMAPTALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL6897569 | 0.89 | MAPT (0.40) | GAAMAPTALDH1A1PKMNPSR1 | |
| SCHEMBL6694644 | 0.89 | AR (0.45) | GAAMAPTALDH1A1PKMPLA2G2A | |
| SCHEMBL6894814 | 0.89 | MAPT (0.44) | GAAMAPTALDH1A1PKMPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395554-B1 | SUBSTITUTED CARBAZOLES AS INHIBITORS OF SPLA2 | LILLY CO ELI (US) | 2007-02-14 | — | — | EP | disclosed |
| EP-0952149-B1 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | LILLY CO ELI (US) | 2004-06-09 | — | — | EP | disclosed |
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |