Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | PRNP | P04156 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | ESRRB | O95718 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18243806 | 0.82 | AKT1 (0.50) | KMT2AGPR139ALDH1A1MAPTHTT | |
| SCHEMBL18113085 | 0.82 | KMT2A (0.55) | KMT2AGPR139ALDH1A1MAPTTSHR | |
| SCHEMBL3048238 | 0.82 | TSHR (0.46) | KMT2AALDH1A1MAPTTSHRKDM4E | |
| SCHEMBL16135529 | 0.81 | ALDH1A1 (0.53) | KMT2AGPR139ALDH1A1MAPTHTT | |
| SCHEMBL29128770 | 0.81 | KMT2A (0.50) | KMT2AGPR139ALDH1A1MAPTHTT | |
| SCHEMBL11276183 | 0.78 | KMT2A (0.48) | KMT2AGPR139ALDH1A1MAPTHTT | |
| SCHEMBL1520392 | 0.78 | KMT2A (0.58) | KMT2AGPR139ALDH1A1MAPTTSHR | |
| SCHEMBL12642206 | 0.78 | GPR139 (0.62) | KMT2AGPR139ALDH1A1MAPTHTT | |
| SCHEMBL8596109 | 0.77 | GPR139 (0.56) | KMT2AGPR139ALDH1A1MAPTHTT | |
| SCHEMBL9787118 | 0.76 | ALDH1A1 (0.59) | KMT2AGPR139ALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10793884-B2 | Methods and materials for making simvastatin and related compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-10-06 | — | — | US | disclosed |
| US-10689628-B2 | Method of making variant LovD polypeptides | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-06-23 | — | — | US | disclosed |
| US-20190169580-A1 | VARIANT LovD POLYPEPTIDE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-06-06 | — | — | US | disclosed |
| US-10246689-B2 | Variant LovD polypeptide | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-04-02 | — | — | US | disclosed |
| US-9970037-B2 | Methods and materials for making simvastatin and related compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-05-15 | — | — | US | disclosed |
| US-9970037-B2 | Methods and materials for making simvastatin and related compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-05-15 | — | — | US | disclosed |
| US-20170029790-A1 | VARIANT LovD POLYPEPTIDE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-02-02 | — | — | US | disclosed |
| US-20170029790-A1 | VARIANT LovD POLYPEPTIDE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-02-02 | — | — | US | disclosed |
| US-9499803-B2 | Variant LovD polypeptide | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-22 | — | — | US | disclosed |
| US-9499803-B2 | Variant LovD polypeptide | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-22 | — | — | US | disclosed |
| US-8951754-B2 | Methods and materials for making simvastatin and related compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-02-10 | — | — | US | disclosed |
| US-20120315680-A1 | METHODS AND MATERIALS FOR MAKING SIMVASTATIN AND RELATED COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-12-13 | — | — | US | disclosed |
| US-20120315680-A1 | METHODS AND MATERIALS FOR MAKING SIMVASTATIN AND RELATED COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-12-13 | — | — | US | disclosed |
| US-20120190038-A1 | LovD MUTANTS EXHIBITING IMPROVED PROPERTIES TOWARDS SIMVASTATIN SYNTHESIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-07-26 | — | — | US | disclosed |
| US-20120190038-A1 | LovD MUTANTS EXHIBITING IMPROVED PROPERTIES TOWARDS SIMVASTATIN SYNTHESIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-07-26 | — | — | US | disclosed |
| US-8211664-B2 | Methods and materials for making simvastatin and related compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-07-03 | — | — | US | disclosed |
| US-8211664-B2 | Methods and materials for making simvastatin and related compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-07-03 | — | — | US | disclosed |
| WO-2011044496-A2 | LovD MUTANTS EXHIBITING IMPROVED PROPERTIES TOWARDS SIMVASTATIN SYNTHESIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-04-14 | — | — | WO | disclosed |
| US-20090191602-A1 | Methods and Materials for Making Simvastatin and Related Compounds | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2009-07-30 | — | — | US | disclosed |
| US-20090191602-A1 | Methods and Materials for Making Simvastatin and Related Compounds | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2009-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170029790-A1 | VARIANT LovD POLYPEPTIDE | FNTA, PCSK9, HMGCR | KMT2A 1901/4885GPR139 3348/4885ALDH1A1 3669/4885 |
| US-10246689-B2 | Variant LovD polypeptide | FNTA, HMGCR, PCSK9 | KMT2A 1938/4885GPR139 3398/4885ALDH1A1 3650/4885 |
| US-20190169580-A1 | VARIANT LovD POLYPEPTIDE | FNTA, HMGCR, PCSK9 | KMT2A 1938/4885GPR139 3398/4885ALDH1A1 3650/4885 |
| US-10689628-B2 | Method of making variant LovD polypeptides | FNTA, HMGCR, COASY | KMT2A 2000/4885GPR139 4072/4885ALDH1A1 2845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.