Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ESRRB | O95718 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 2/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8596105 | 0.82 | GPR139 (0.56) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL9352752 | 0.82 | GPR139 (0.56) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL6381157 | 0.79 | GPR139 (0.58) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL6889605 | 0.77 | KMT2A (0.54) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL11097673 | 0.77 | GPR139 (0.63) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL8123498 | 0.76 | GPR139 (0.71) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL8123489 | 0.76 | GPR139 (0.71) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL8243432 | 0.75 | NPC1 (0.55) | ALDH1A1L3MBTL1C3AR1FOLH1 | |
| SCHEMBL2249325 | 0.75 | NPC1 (0.55) | ALDH1A1L3MBTL1C3AR1FOLH1 | |
| SCHEMBL11113484 | 0.74 | FNTA (0.59) | ALDH1A1FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0710228-B1 | HYDRAZINO-TYPE RADIONUCLIDE CHELATORS HAVING AN N 3?S CONFIGURATION | RESOLUTION PHARM INC (CA) | 1998-01-21 | — | — | EP | disclosed |
| US-5659041-A | MEDICAL DIAGNOSIS, THERAPY | RESOLUTION PHARMACEUTICALS, INC. (CA) | 1997-08-19 | — | — | US | disclosed |
| US-5643780-A | CONTROLLING PROTEIN EXPRESSION IN CELLS | ISIS PHARMACEUTICALS, INC. (US) | 1997-07-01 | — | — | US | disclosed |
| EP-0710228-A1 | HYDRAZINO-TYPE RADIONUCLIDE CHELATORS HAVING AN N 3?S CONFIGURATION | RESOLUTION PHARMACEUTICALS INC. (CA) | 1996-05-08 | — | — | EP | disclosed |
| WO-1995003280-A1 | HYDRAZINO-TYPE RADIONUCLIDE CHELATORS HAVING AN N3S CONFIGURATION | RESOLUTION PHARMACEUTICALS INC. (CA) | 1995-02-02 | — | — | WO | disclosed |