Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 2/20 | 0.39 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6890484 | 1.00 | TRIM24 (0.39) | TRIM24TRIM33ALDH1A1MEN1CYP2C9 | |
| SCHEMBL3309008 | 0.90 | TRIM24 (0.43) | TRIM24TRIM33ALDH1A1MEN1CYP2C9 | |
| SCHEMBL3304905 | 0.90 | TRIM24 (0.43) | TRIM24TRIM33ALDH1A1MEN1CYP2C9 | |
| SCHEMBL6882890 | 0.82 | — | — | |
| SCHEMBL6889421 | 0.79 | — | — | |
| SCHEMBL8603903 | 0.76 | ALDH1A1 (0.46) | TRIM24TRIM33ALDH1A1MEN1KMT2A | |
| SCHEMBL515266 | 0.74 | TRIM24 (0.47) | TRIM24TRIM33ALDH1A1MEN1CYP2C9 | |
| SCHEMBL515401 | 0.74 | TRIM24 (0.47) | TRIM24TRIM33ALDH1A1MEN1CYP2C9 | |
| SCHEMBL136359 | 0.71 | TRIM24 (0.44) | TRIM24TRIM33ALDH1A1MEN1CYP2C9 | |
| SCHEMBL515798 | 0.70 | TRIM24 (0.50) | TRIM24TRIM33ALDH1A1MEN1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414813-A1 | 1,2,4-TRIOXOLANE ANTIMALARIALS | Medicines for Malaria Venture (CH) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003000676-A1 | 1,2,4-TRIOXOLANE ANTIMALARIALS | MEDICINES FOR MALARIA VENTURE (CH) | 2003-01-03 | — | — | WO | disclosed |
| US-6486199-B1 | Spiro and dispiro 1,2,4-trioxolane antimalarials | MEDICINES FOR MALARIA VENTURE MMV INTERNATIONAL CENTRE COINTRIN (CH) | 2002-11-26 | — | — | US | disclosed |