Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.44 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.44 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | ACACA | Q13085 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.37 |
| ▸ | JUN | P05412 | 4/20 | 0.37 |
| ▸ | CDK2 | P24941 | 4/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6893503 | 0.88 | MTOR (0.44) | MTORRPTORMLST8MAPK8MAPK9 | |
| SCHEMBL6890126 | 0.86 | MTOR (0.49) | MTORRPTORMLST8ACACBACACA | |
| SCHEMBL16104566 | 0.85 | MTOR (0.49) | MTORRPTORMLST8ACACBACACA | |
| SCHEMBL6893613 | 0.84 | MTOR (0.46) | MTORRPTORMLST8CDK2MAPT | |
| SCHEMBL40378 | 0.80 | MTOR (0.42) | MTORRPTORMLST8ACACBACACA | |
| SCHEMBL6891287 | 0.77 | MTOR (0.48) | MTORRPTORMLST8ACACBACACA | |
| SCHEMBL6891641 | 0.76 | PIK3CD (0.41) | MTORRPTORMLST8ACACBACACA | |
| SCHEMBL7886685 | 0.75 | CHEK1 (0.41) | MTORRPTORMLST8ACACBACACA | |
| SCHEMBL10240157 | 0.75 | MTOR (0.44) | MTORRPTORMLST8ACACBACACA | |
| SCHEMBL10234699 | 0.74 | MTOR (0.42) | MTORRPTORMLST8ACACBACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002887-A1 | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS | SCHERING CORPORATION (US) | 2011-01-06 | — | — | WO | disclosed |