Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.41 |
| ▸ | MTOR | P42345 | 3/20 | 0.41 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.41 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | NPM1 | P06748 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FGR | P09769 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | KIF5B | P33176 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6894519 | 0.89 | MTOR (0.40) | PIK3CDMTORRPTORMLST8JAK1 | |
| SCHEMBL6890126 | 0.87 | MTOR (0.49) | MTORRPTORMLST8JAK1ACACB | |
| SCHEMBL1022445 | 0.84 | RET (0.49) | MTORRPTORMLST8ABL1LCK | |
| SCHEMBL6891287 | 0.78 | MTOR (0.48) | MTORRPTORMLST8JAK1ACACB | |
| SCHEMBL6891435 | 0.76 | MTOR (0.44) | MTORRPTORMLST8JAK1ACACB | |
| SCHEMBL6894512 | 0.75 | MTOR (0.48) | PIK3CDMTORRPTORMLST8JAK1 | |
| SCHEMBL16104566 | 0.75 | MTOR (0.49) | PIK3CDMTORRPTORMLST8JAK1 | |
| SCHEMBL1073541 | 0.75 | MTOR (0.40) | PIK3CDMTORRPTORMLST8JAK1 | |
| SCHEMBL1023287 | 0.75 | MTOR (0.53) | MTORRPTORMLST8JAK1 | |
| SCHEMBL18318748 | 0.74 | EPHX2 (0.47) | PIK3CDACACBACACAPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002887-A1 | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS | SCHERING CORPORATION (US) | 2011-01-06 | — | — | WO | disclosed |