Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | RARA | P10276 | 3/20 | 0.60 |
| ▸ | RARB | P10826 | 3/20 | 0.60 |
| ▸ | RARG | P13631 | 3/20 | 0.60 |
| ▸ | RXRA | P19793 | 3/20 | 0.60 |
| ▸ | RXRB | P28702 | 1/20 | 0.60 |
| ▸ | RXRG | P48443 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 6/20 | 0.58 |
| ▸ | RAB9A | P51151 | 6/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.57 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5538662 | 0.89 | RXRA (0.64) | CYP2C9RXFP1RARARARBRARG | |
| SCHEMBL1074782 | 0.88 | RXRA (0.62) | CYP2C9RARARARBRARGRXRA | |
| SCHEMBL8461267 | 0.83 | RARA (0.76) | CYP2C9RARARARBRARGNPC1 | |
| SCHEMBL1072538 | 0.82 | RXRA (0.67) | RARARARBRARGRXRARXRB | |
| SCHEMBL5537933 | 0.81 | RARA (0.60) | CYP2C9RXFP1RARARARBRARG | |
| SCHEMBL12181011 | 0.81 | RXRA (0.88) | RARARARBRARGRXRARXRB | |
| SCHEMBL6889482 | 0.81 | RXRA (0.58) | CYP2C9RARARARBRARGRXRA | |
| SCHEMBL1073921 | 0.80 | RXRA (0.76) | RARARARBRARGRXRARXRB | |
| SCHEMBL3982018 | 0.80 | RXRA (0.72) | RARARARBRARGRXRARXRB | |
| SCHEMBL8769709 | 0.78 | RAB9A (0.89) | CYP2C9RXFP1NPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011006157-A2 | RXR AGONIST COMPOUNDS AND METHODS | CASE WESTERN RESERVE UNIVERSITY (US) | 2011-01-13 | — | — | WO | disclosed |