Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 3/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28956318 | 0.83 | AKR1C1 (0.41) | TDP1BLMPMP22TSHRBACE1 | |
| SCHEMBL1844160 | 0.80 | F2 (0.37) | BLMRECQLBACE1BACE2KMT2A | |
| SCHEMBL28215026 | 0.72 | TDP1 (0.33) | MAPTTDP1BLMPMP22HSD17B10 | |
| SCHEMBL15136482 | 0.68 | MAPT (0.36) | MAPTTDP1BLMPMP22HSD17B10 | |
| SCHEMBL1284435 | 0.67 | KMT2A (0.32) | MAPTTDP1BLMPMP22POLB | |
| SCHEMBL11264366 | 0.66 | LMNA (0.38) | MAPTBLMPMP22BACE1BACE2 | |
| SCHEMBL11093099 | 0.64 | CTSD (0.34) | MAPTTDP1BLMPMP22HSD17B10 | |
| SCHEMBL3969182 | 0.64 | BACE1 (0.34) | MAPTBLMPMP22BACE1BACE2 | |
| SCHEMBL2722547 | 0.64 | AKR1C1 (0.57) | AKR1C1KMT2AHDAC4THRBCYP2C9 | |
| SCHEMBL501923 | 0.64 | AKR1C1 (0.57) | AKR1C1KMT2AHDAC4THRBCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391457-A1 | Substituted 2-Phenylbenzimidazoles and their use as PARP inhibitors | Abbott GmbH & Co. KG (DE) | 2004-02-25 | — | — | EP | disclosed |