SCHEMBL68914

SCHEMBL68914

Cc1cc(C)c2c(c1)C(=O)C(C)O2

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SIRT2 Q8IXJ6 1/20 0.44
ACHE P22303 1/20 0.33
GRIN2D O15399 1/20 0.33
GRIN3B O60391 1/20 0.33
GRIN1 Q05586 1/20 0.33
GRIN2A Q12879 1/20 0.33
GRIN2B Q13224 1/20 0.33
GRIN2C Q14957 1/20 0.33
GRIN3A Q8TCU5 1/20 0.33
HSD17B10 Q99714 1/20 0.33
PTGS2 P35354 2/20 0.33
PTGS1 P23219 1/20 0.33
ESR1 P03372 1/20 0.31
ESR2 Q92731 1/20 0.31
NQO1 P15559 1/20 0.30
POR P16435 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30576350 1.00 SIRT2 (0.44) SIRT2ACHEGRIN2DGRIN3BGRIN1
SCHEMBL69719 0.69 CYP19A1 (0.46) ACHEESR1
SCHEMBL30576378 0.69 CYP19A1 (0.46) ACHEESR1
SCHEMBL4967527 0.69 PARP1 (0.45)
SCHEMBL24227357 0.68 SIRT2 (0.35) SIRT2HSD17B10
SCHEMBL24227345 0.66 SIRT2 (0.34) SIRT2HSD17B10
SCHEMBL658224 0.65 ESR1 (0.37) ESR1ESR2
SCHEMBL28417820 0.63 ESR2 (0.65) ESR1ESR2
SCHEMBL14883877 0.63 SIRT2 (0.45) SIRT2
SCHEMBL7982265 0.62 NOS3 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3865480-B1 HYDRAZINE DERIVATIVES FMC CORP (US) 2025-11-05 EP disclosed
CN-111018790-B Pyridazinone herbicides FMC公司 2023-09-19 CN disclosed
EP-3865480-A1 HYDRAZINE DERIVATIVES FMC Corporation (US) 2021-08-18 EP disclosed
EP-3137456-B1 PYRIDAZINONE HERBICIDES FMC CORP (US) 2021-06-02 EP disclosed
CN-111018790-A Pyridazinone herbicides FMC公司 2020-04-17 CN disclosed
US-10597388-B2 Pyridazinone herbicides FMC CORPORATION (US) 2020-03-24 US disclosed
CN-106458926-B Pyridazinone herbicides FMC公司 2020-01-03 CN disclosed
US-20190016712-A1 PYRIDAZINONE HERBICIDES FMC CORPORATION 2019-01-17 US disclosed
US-10118917-B2 Pyridazinone herbicides FMC CORPORATION 2018-11-06 US disclosed
US-20170050953-A1 PYRIDAZINONE HERBICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2017-02-23 US disclosed
EP-2042563-A1 Photocurable coating composition, and overprint and process for producing same FUJIFILM Corporation (JP) 2009-04-01 EP disclosed
EP-2042573-A1 Ink composition FUJIFILM Corporation (JP) 2009-04-01 EP disclosed
US-20090081421-A1 PHOTOCURABLE COATING COMPOSITION, AND OVERPRINT AND PROCESS FOR PRODUCING SAME FUJIFILM CORPORATION (JP) 2009-03-26 US disclosed
US-20090081421-A1 PHOTOCURABLE COATING COMPOSITION, AND OVERPRINT AND PROCESS FOR PRODUCING SAME FUJIFILM CORPORATION (JP) 2009-03-26 US disclosed
US-20080239045-A1 INK SET FOR INKJET RECORDING AND INKJET RECORDING METHOD FUJIFILM CORPORATION (JP) 2008-10-02 US disclosed
US-20080239045-A1 INK SET FOR INKJET RECORDING AND INKJET RECORDING METHOD FUJIFILM CORPORATION (JP) 2008-10-02 US disclosed
EP-1975210-A1 Ink set for inkjet recording and inkjet recording method FUJIFILM Corporation (JP) 2008-10-01 EP disclosed
US-20080182031-A1 Sensitizing dye, an alpha-aminoketone or acyl phosphine oxide polymerization initiator and an ethylenically unsaturated bond-containing polymerizable compound FUJIFILM CORPORATION (JP) 2008-07-31 US disclosed
US-20080182031-A1 Sensitizing dye, an alpha-aminoketone or acyl phosphine oxide polymerization initiator and an ethylenically unsaturated bond-containing polymerizable compound FUJIFILM CORPORATION (JP) 2008-07-31 US disclosed
EP-1944173-A1 Ink composition and inkjet recording method using the same FUJIFILM Corporation (JP) 2008-07-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190016712-A1 PYRIDAZINONE HERBICIDES CBR3, NOX5, NR5A2 SIRT2 1298/4885ACHE 428/4885GRIN2D 967/4885
US-20170050953-A1 PYRIDAZINONE HERBICIDES CBR3, NOX5, NR5A2 SIRT2 1298/4885ACHE 428/4885GRIN2D 967/4885
US-10118917-B2 Pyridazinone herbicides CBR3, NOX5, NR5A2 SIRT2 1298/4885ACHE 428/4885GRIN2D 967/4885
US-10597388-B2 Pyridazinone herbicides CBR3, NOX5, NR5A2 SIRT2 1298/4885ACHE 428/4885GRIN2D 967/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.