Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 3/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5212605 | 0.93 | MAPK8 (0.42) | PLA2G2AMAPTTHRBAGTR1 | |
| SCHEMBL6893888 | 0.91 | PLA2G2A (0.47) | PLA2G2AMAPTPOLBTP53THRB | |
| SCHEMBL6896800 | 0.90 | MAPT (0.43) | MAPTPOLBCNR2CNR1TP53 | |
| SCHEMBL6889327 | 0.89 | MAPT (0.41) | MAPTPOLBCNR2TP53 | |
| SCHEMBL6897945 | 0.89 | POLB (0.36) | POLB | |
| SCHEMBL6774931 | 0.89 | PLA2G2A (0.48) | PLA2G2ACNR2CNR1TP53THRB | |
| SCHEMBL6888047 | 0.88 | CNR1 (0.38) | MAPTCNR2CNR1AGTR1 | |
| SCHEMBL6889205 | 0.88 | MAPK8 (0.41) | PLA2G2AAGTR1PLA2G1B | |
| SCHEMBL6897075 | 0.88 | CETP (0.41) | — | |
| SCHEMBL6895127 | 0.87 | CNR1 (0.42) | MAPTCNR2CNR1TP53PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |