Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | MDH1 | P40925 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5212605 | 0.91 | MAPK8 (0.42) | PLK1MAPK8PPARAALDH1A1 | |
| SCHEMBL6895193 | 0.91 | POLB (0.39) | POLBMAPK8F10P2RX7 | |
| SCHEMBL6896800 | 0.90 | MAPT (0.43) | POLBCYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL6889327 | 0.89 | MAPT (0.41) | POLBF10ALDH1A1 | |
| SCHEMBL6891901 | 0.89 | PLA2G2A (0.43) | POLB | |
| SCHEMBL6773827 | 0.89 | PPARG (0.39) | POLBMAPK8F10PPARA | |
| SCHEMBL6888047 | 0.88 | CNR1 (0.38) | PLK1MAPK8PPARAALDH1A1 | |
| SCHEMBL6889205 | 0.88 | MAPK8 (0.41) | PLK1MAPK8PPARA | |
| SCHEMBL6897075 | 0.88 | CETP (0.41) | PPARAALDH1A1 | |
| SCHEMBL6892057 | 0.87 | HSP90AA1 (0.37) | PLK1MDH1CYP1A2CYP2C19PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |