Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | CFTR | P13569 | 4/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5212605 | 0.93 | MAPK8 (0.42) | PPARGPPARAALDH1A1 | |
| SCHEMBL6896777 | 0.91 | FAAH (0.44) | FAAHALDH1A1CCR8 | |
| SCHEMBL6776640 | 0.90 | CETP (0.41) | CETPPPARGPPARACFTR | |
| SCHEMBL6889205 | 0.90 | MAPK8 (0.41) | PPARGPPARAHDAC1 | |
| SCHEMBL6888047 | 0.90 | CNR1 (0.38) | PPARGPPARAALDH1A1 | |
| SCHEMBL6888714 | 0.89 | TSPO (0.39) | — | |
| SCHEMBL6897889 | 0.89 | CNR2 (0.38) | PPARG | |
| SCHEMBL6896800 | 0.88 | MAPT (0.43) | ALDH1A1 | |
| SCHEMBL6891901 | 0.88 | PLA2G2A (0.43) | — | |
| SCHEMBL6889327 | 0.88 | MAPT (0.41) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |