Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 12/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6797369 | 0.85 | OPRD1 (0.60) | OPRD1OPRM1OPRK1ALDH1A1HPGD | |
| SCHEMBL4678352 | 0.81 | OPRD1 (0.65) | OPRD1OPRM1OPRK1ALDH1A1HPGD | |
| SCHEMBL6248099 | 0.81 | CYP1A2 (0.51) | OPRD1OPRM1OPRK1ALDH1A1HPGD | |
| SCHEMBL4576604 | 0.81 | ALDH1A1 (0.65) | OPRD1OPRM1OPRK1ALDH1A1HPGD | |
| SCHEMBL8527824 | 0.81 | HPGD (0.58) | OPRD1OPRM1OPRK1ALDH1A1HPGD | |
| SCHEMBL6795823 | 0.77 | OPRD1 (1.00) | OPRD1OPRM1OPRK1 | |
| SCHEMBL27472898 | 0.77 | OPRD1 (0.74) | OPRD1OPRM1OPRK1 | |
| Acetic Acid SCHEMBL28094249 | 0.76 | ALDH1A1 (0.53) | ALDH1A1HPGDMAPT | |
| SCHEMBL6973873 | 0.75 | ALDH1A1 (0.51) | OPRD1OPRM1OPRK1ALDH1A1HPGD | |
| SCHEMBL2152243 | 0.75 | KMT2A (0.45) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1408037-A1 | Novel diarylmethylpiperazine and diarylmethylphenyl compounds with analgesic effect | AstraZeneca AB (SE) | 2004-04-14 | — | — | EP | disclosed |
| US-6130222-A | Compounds with analgesic effect | ASTRA PHARMA INC. (CA) | 2000-10-10 | — | — | US | disclosed |
| EP-0915855-A1 | NOVEL COMPOUNDS WITH ANALGESIC EFFECT | Astra Pharma Inc. (CA) | 1999-05-19 | — | — | EP | disclosed |