Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 11/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.65 |
| ▸ | RECQL | P46063 | 3/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | CASP6 | P55212 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.60 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30861636 | 1.00 | POLB (0.72) | POLBALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL2363298 | 0.97 | ALDH1A1 (0.72) | POLBALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL30861620 | 0.95 | ALDH1A1 (0.70) | POLBALDH1A1KDM4EMAPTHPGD | |
| Water SCHEMBL3871916 | 0.95 | ALDH1A1 (0.70) | POLBALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL12850775 | 0.88 | POLB (0.72) | POLBALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL22208005 | 0.84 | ALDH1A1 (0.68) | POLBALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL9634628 | 0.84 | ALDH1A1 (0.68) | POLBALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL11837932 | 0.83 | POLB (0.52) | POLBALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL11842866 | 0.83 | POLB (0.52) | POLBALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL22224161 | 0.78 | ALDH1A1 (0.64) | POLBALDH1A1KDM4EMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3908306-A1 | PHOSPHATASE BINDING COMPOUNDS AND METHODS OF USING SAME | Yale University (US) | 2021-11-17 | — | — | EP | disclosed |
| US-20200268897-A1 | Phosphatase Binding Compounds and Methods of Using Same | YALE UNIVERSITY | 2020-08-27 | — | — | US | disclosed |
| WO-2020146470-A1 | Phosphatase Binding Compounds and Methods of Using Same | YALE UNIVERSITY (US) | 2020-07-16 | — | — | WO | disclosed |
| US-9447047-B2 | Inhibitors of protein phosphatase-1 and uses thereof | HOWARD UNIVERSITY (US) | 2016-09-20 | — | — | US | disclosed |
| US-20160024013-A1 | Inhibitors of Protein Phosphatase-1 and Uses Thereof | HOWARD UNIVERSITY | 2016-01-28 | — | — | US | disclosed |
| US-8278326-B2 | Inhibitors of protein phosphatase-1 and uses thereof | HOWARD UNIVERSITY (US) | 2012-10-02 | — | — | US | disclosed |
| US-20090264463-A1 | Inhibitors Of Protein Phosphatase-1 And Uses Thereof | HOWARD UNIVERSITY | 2009-10-22 | — | — | US | disclosed |
| US-20040082079-A1 | Low affinity screening method | GRAFFINITY PHARMACEUTICALS AG. (DE) | 2004-04-29 | — | — | US | disclosed |
| EP-1360489-A1 | LOW AFFINITY SCREENING METHOD | Graffinity Pharmaceuticals Aktiengesellschaft (DE) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002063299-A1 | LOW AFFINITY SCREENING METHOD | GRAFFINITY PHARMACEUTICALS AG (DE) | 2002-08-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024013-A1 | Inhibitors of Protein Phosphatase-1 and Uses Thereof | PPM1F, PPM1A, PPM1G | POLB 2089/4885ALDH1A1 3129/4885KDM4E 2960/4885 |
| US-20200268897-A1 | Phosphatase Binding Compounds and Methods of Using Same | PPP5C, PPP4C, DUSP26 | POLB 2253/4885ALDH1A1 3756/4885KDM4E 2696/4885 |
| US-20090264463-A1 | Inhibitors Of Protein Phosphatase-1 And Uses Thereof | PPM1A, PPP1R15A, PPM1F | POLB 1368/4885ALDH1A1 3090/4885KDM4E 2024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.