Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHCY | P23526 | 5/20 | 0.55 |
| ▸ | NADK | O95544 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.53 |
| ▸ | DNMT1 | P26358 | 3/20 | 0.52 |
| ▸ | DNMT3B | Q9UBC3 | 3/20 | 0.52 |
| ▸ | AMD1 | P17707 | 1/20 | 0.52 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.51 |
| ▸ | DPP4 | P27487 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.51 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.51 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.51 |
| ▸ | GAPDH | P04406 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | STAT6 | P42226 | 1/20 | 0.51 |
| ▸ | PI4KA | P42356 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6908435 | 1.00 | AHCY (0.55) | AHCYNADKADORA3DNMT1DNMT3B | |
| SCHEMBL6907874 | 0.90 | AHCY (0.47) | AHCYNADKADORA3DNMT1DNMT3B | |
| SCHEMBL6907886 | 0.90 | AHCY (0.47) | AHCYNADKADORA3DNMT1DNMT3B | |
| SCHEMBL9218364 | 0.84 | ADORA1 (0.62) | ADORA3EHMT1DPP4MEN1SLC28A1 | |
| SCHEMBL22875578 | 0.84 | ADORA1 (0.62) | ADORA3EHMT1DPP4MEN1SLC28A1 | |
| SCHEMBL5794947 | 0.81 | ADORA1 (0.61) | AHCYNADKADORA3EHMT1DPP4 | |
| SCHEMBL5822306 | 0.80 | ADORA3 (0.53) | ADORA3EHMT1DPP4MEN1SLC28A1 | |
| SCHEMBL5822309 | 0.80 | ADORA3 (0.53) | ADORA3EHMT1DPP4MEN1SLC28A1 | |
| Methylthioadenosine SCHEMBL890628 | 0.79 | AHCY (0.83) | AHCYNADKADORA3DNMT1DNMT3B | |
| Methylthioadenosine SCHEMBL20798030 | 0.79 | AHCY (0.83) | AHCYNADKADORA3DNMT1DNMT3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482977-A1 | COMBINATION THERAPIES FOR TREATING METHYLTHIOADENOSINE PHOSPHORYLASE DEFICIENT CELLS | PFIZER INC. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003074083-A1 | COMBINATION THERAPIES FOR TREATING METHYLTHIOADENOSINE PHOSPHORYLASE DEFICIENT CELLS | PFIZER INC. (US) | 2003-09-12 | — | — | WO | disclosed |