Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL449803 | 0.91 | HRH3 (0.51) | HRH3KDM4EALDH1A1TDP1ACHE | |
| SCHEMBL1655800 | 0.79 | ACHE (0.48) | HRH3ACHECYP19A1SIGMAR1 | |
| SCHEMBL4363192 | 0.75 | LTA4H (0.54) | HRH3KDM4EALDH1A1TDP1 | |
| SCHEMBL445318 | 0.74 | LTA4H (0.53) | HRH3KDM4EALDH1A1TDP1 | |
| SCHEMBL6230486 | 0.74 | ACHE (0.44) | HRH3ACHECYP19A1SIGMAR1CTSS | |
| SCHEMBL24192958 | 0.73 | TDP1 (0.42) | HRH3KDM4EALDH1A1TDP1ACHE | |
| SCHEMBL444846 | 0.73 | HRH3 (0.41) | HRH3 | |
| SCHEMBL4367645 | 0.73 | HRH3 (0.52) | HRH3KDM4EALDH1A1TDP1CYP19A1 | |
| SCHEMBL4375016 | 0.73 | CHRNB4 (0.61) | — | |
| SCHEMBL4375014 | 0.73 | CHRNB4 (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467721-A2 | SUBSTITUTED AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF ANGIOGENESIS | Amgen Inc. (US) | 2004-10-20 | — | — | EP | disclosed |
| WO-2002068406-A2 | SUBSTITUTED AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF ANGIOGENESIS | AMGEN INC. (US) | 2002-09-06 | — | — | WO | disclosed |