3,4,5-Trimethoxybenzamide

3,4,5-Trimethoxybenzamide

SCHEMBL6894482

COc1cc(C(N)=O)cc(OC)c1OC.NC(=O)Cc1ccc(Cl)c(Cl)c1

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.56
GAA P10253 1/20 0.56
CRHBP P24387 1/20 0.56
CRHR2 Q13324 1/20 0.56
HTT P42858 2/20 0.49
TSHR P16473 2/20 0.49
APOBEC3A P31941 1/20 0.49
APOBEC3G Q9HC16 1/20 0.49
SLC6A4 P31645 3/20 0.47
HTR2A P28223 1/20 0.47
BPTF Q12830 1/20 0.44
SLC6A2 P23975 2/20 0.43
SLC6A3 Q01959 2/20 0.43
CDK8 P49336 1/20 0.43
CLK4 Q9HAZ1 1/20 0.43
HIF1A Q16665 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27590527 0.79 HSD17B10 (0.57) LMNAGAACRHBPCRHR2HTT
SCHEMBL1029174 0.78 SLC6A4 (0.54) LMNATSHRSLC6A4HTR2ASLC6A2
3,4,5-Trimethoxybenzamide SCHEMBL1326890 0.77 TSHR (0.76) HTTTSHRAPOBEC3AAPOBEC3GBPTF
SCHEMBL5207216 0.76 LMNA (0.67) LMNAGAACRHBPCRHR2HTT
SCHEMBL14045969 0.76 ALDH1A1 (0.66) LMNAGAAHTTTSHRAPOBEC3A
SCHEMBL1991744 0.75 PTGS2 (0.53) LMNAGAAHTTTSHRHTR2A
SCHEMBL365312 0.75 SLC6A4 (0.67) LMNAGAACRHBPCRHR2TSHR
3,4,5-Trimethoxybenzamide SCHEMBL4381076 0.75 TSHR (0.73) HTTTSHRAPOBEC3AAPOBEC3GBPTF
SCHEMBL1033641 0.72 LMNA (0.61) LMNAGAAHTT
SCHEMBL29602721 0.72 LMNA (0.61) LMNAGAAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1126833-A4 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES INC (US) 2004-09-08 EP claimed
EP-1126833-A2 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES, INC. (US) 2001-08-29 EP claimed
WO-2000025768-A1 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES, INC. (US) 2000-05-11 WO claimed