SCHEMBL6894771

SCHEMBL6894771

O=[N+]([O-])c1ccc(N=C=S)cc1.S=C=Nc1ccc(Oc2ccccc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.50
HSPB1 P04792 1/20 0.50
KDM4E B2RXH2 1/20 0.50
MEN1 O00255 4/20 0.49
KMT2A Q03164 4/20 0.49
MAPT P10636 3/20 0.49
MAPK1 P28482 3/20 0.49
LMNA P02545 3/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
MIF P14174 1/20 0.47
SRD5A2 P31213 1/20 0.47
FFAR1 O14842 1/20 0.46
NR3C1 P04150 1/20 0.45
RAB9A P51151 3/20 0.44
MCL1 Q07820 1/20 0.44
NPC1 O15118 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
MYOC Q99972 1/20 0.44
DRD2 P14416 1/20 0.43
DRD4 P21917 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nitroscanate SCHEMBL381451 0.94 HSPB1 (0.56) ALDH1A1HSPB1KDM4EMEN1KMT2A
SCHEMBL206480 0.85 PLAU (0.50) ALDH1A1HSPB1MEN1KMT2AMAPT
Isothiocyanate SCHEMBL6153714 0.84 HSPB1 (0.56) ALDH1A1HSPB1KDM4EMEN1KMT2A
SCHEMBL3823434 0.83 MIF (0.67) MIF
SCHEMBL457863 0.83 HSPB1 (0.68) ALDH1A1HSPB1KDM4EMEN1KMT2A
SCHEMBL11593921 0.81 HSPB1 (0.56) ALDH1A1HSPB1KDM4EMEN1KMT2A
Nitrobenzene SCHEMBL27619235 0.80 ALDH1A1 (0.52) ALDH1A1MEN1KMT2AMAPTMAPK1
Diphenylether SCHEMBL28998326 0.78 ALDH1A1 (0.73) ALDH1A1HSPB1KDM4EMEN1KMT2A
SCHEMBL11708240 0.77 HSPB1 (0.64) ALDH1A1HSPB1KDM4EMEN1KMT2A
Amoscanate SCHEMBL159478 0.76 HPGD (0.56) ALDH1A1KDM4EMEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1126833-A4 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES INC (US) 2004-09-08 EP disclosed
EP-1126833-A2 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES, INC. (US) 2001-08-29 EP disclosed
WO-2000025768-A1 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES, INC. (US) 2000-05-11 WO disclosed