Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 5/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6895550 | 0.91 | KIF11 (0.42) | HSP90AA1HSP90B1KIF11RORCP2RX7 | |
| SCHEMBL6777171 | 0.90 | CYP3A4 (0.38) | KIF11TRPV1RORCEPHX2PLK1 | |
| SCHEMBL6895065 | 0.89 | LMNA (0.40) | HSP90AA1HSP90B1PLK1KDM4EALDH1A1 | |
| SCHEMBL6897067 | 0.88 | CNR1 (0.41) | HSP90AA1HSP90B1PLK1KDM4EALDH1A1 | |
| SCHEMBL6895127 | 0.87 | CNR1 (0.42) | HSP90AA1HSP90B1CYP2C9KDM4EALDH1A1 | |
| SCHEMBL6892057 | 0.87 | HSP90AA1 (0.37) | HSP90AA1HSP90B1PLK1KDM4EALDH1A1 | |
| SCHEMBL5212605 | 0.86 | MAPK8 (0.42) | TRPV1PLK1ALDH1A1PPARG | |
| SCHEMBL6898238 | 0.86 | TRPV1 (0.46) | TRPV1PLK1KDM4EALDH1A1PPARG | |
| SCHEMBL6894406 | 0.86 | MAPK8 (0.42) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL6896241 | 0.86 | CNR1 (0.42) | HSP90AA1PLK1CYP2C9KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |