Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6892764 | 0.91 | LMNA (0.44) | LMNAL3MBTL1KDM4EALDH1A1KMT2A | |
| SCHEMBL6897067 | 0.90 | CNR1 (0.41) | LMNAL3MBTL1KDM4EALDH1A1KMT2A | |
| SCHEMBL6782670 | 0.90 | ALDH1A1 (0.39) | LMNAL3MBTL1KDM4EALDH1A1RAB9A | |
| SCHEMBL6892057 | 0.89 | HSP90AA1 (0.37) | KDM4EALDH1A1KMT2AMEN1HSP90AA1 | |
| SCHEMBL6895127 | 0.89 | CNR1 (0.42) | LMNAKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL5212605 | 0.89 | MAPK8 (0.42) | ALDH1A1THRBAGTR1AGTR2MAPT | |
| SCHEMBL6894818 | 0.89 | HSP90AA1 (0.39) | KDM4EALDH1A1KMT2AMEN1HSP90AA1 | |
| SCHEMBL6894406 | 0.88 | MAPK8 (0.42) | KDM4EALDH1A1KMT2AMEN1CNR2 | |
| SCHEMBL6896241 | 0.88 | CNR1 (0.42) | KDM4EALDH1A1KMT2AMEN1HSP90AA1 | |
| SCHEMBL6893816 | 0.88 | PLA2G2A (0.42) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |