Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 12/20 | 0.56 |
| ▸ | EDNRB | P24530 | 8/20 | 0.56 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4769508 | 0.85 | EDNRA (0.58) | EDNRAEDNRBAGTR1 | |
| SCHEMBL4770839 | 0.84 | EDNRA (0.56) | EDNRAEDNRB | |
| SCHEMBL7948222 | 0.76 | EDNRA (0.74) | EDNRAEDNRB | |
| SCHEMBL6773334 | 0.75 | EDNRA (0.75) | EDNRAEDNRB | |
| SCHEMBL4769784 | 0.74 | AGTR1 (0.54) | EDNRAEDNRBAGTR1 | |
| SCHEMBL6897288 | 0.74 | EDNRA (0.65) | EDNRAAGTR1 | |
| SCHEMBL6892200 | 0.74 | EDNRA (0.72) | EDNRAAGTR1 | |
| SCHEMBL7947185 | 0.73 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL4769409 | 0.73 | AGTR1 (0.50) | EDNRAEDNRBAGTR1 | |
| SCHEMBL6771792 | 0.73 | EDNRA (0.72) | EDNRAEDNRBAGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6835741-B2 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY | 2004-12-28 | — | — | US | disclosed |