Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.38 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6776586 | 0.89 | MAPT (0.42) | PPARGMAPTMAPK10KDM4EALDH1A1 | |
| SCHEMBL6693179 | 0.89 | PPARG (0.48) | PPARGMAPTMAPK10KDM4EALDH1A1 | |
| SCHEMBL6897981 | 0.88 | PPARG (0.45) | PPARGMAPTMAPK10KDM4EALDH1A1 | |
| SCHEMBL6893146 | 0.88 | PPARG (0.45) | PPARGMAPTMAPK10KDM4EALDH1A1 | |
| SCHEMBL6895034 | 0.88 | L3MBTL1 (0.43) | MAPTKDM4EALDH1A1SMN1; SMN2F10 | |
| SCHEMBL6694748 | 0.88 | MAPT (0.43) | MAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6895041 | 0.87 | MAPT (0.45) | MAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6898645 | 0.86 | PPARG (0.48) | PPARGMAPTMAPK10KDM4EALDH1A1 | |
| SCHEMBL6897629 | 0.86 | POLB (0.36) | MAPTF10 | |
| SCHEMBL6895778 | 0.86 | PLA2G2A (0.45) | MAPTMAPK10ALDH1A1PTGER4F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |