Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 9/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6694748 | 0.92 | MAPT (0.43) | PLA2G2AMAPTALDH1A1 | |
| SCHEMBL6895041 | 0.89 | MAPT (0.45) | MAPTPOLBALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL6897629 | 0.89 | POLB (0.36) | MAPTPOLBF10 | |
| SCHEMBL6895034 | 0.89 | L3MBTL1 (0.43) | MAPTPOLBALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL6771712 | 0.88 | PLA2G2A (0.51) | PLA2G2AMAPTCCR2PTGER4PTGDR | |
| SCHEMBL6694412 | 0.88 | PLA2G2A (0.56) | PLA2G2AMAPTPOLBCCR2ALDH1A1 | |
| SCHEMBL6894722 | 0.88 | PLA2G2A (0.41) | PLA2G2AMAPTALDH1A1PLA2G1B | |
| SCHEMBL6890656 | 0.88 | THRB (0.37) | MAPTALDH1A1F10 | |
| SCHEMBL6893888 | 0.87 | PLA2G2A (0.47) | PLA2G2AMAPTPOLBCCR2ALDH1A1 | |
| SCHEMBL6889588 | 0.87 | PLA2G2A (0.49) | PLA2G2AMAPTPOLBCCR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |