Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | YWHAH | Q04917 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6694748 | 0.91 | MAPT (0.43) | PLA2G2AMAPTALDH1A1TSHRTHRB | |
| SCHEMBL6890656 | 0.91 | THRB (0.37) | MAPTALDH1A1THRBYWHAHGAA | |
| SCHEMBL6774469 | 0.90 | PLA2G2A (0.41) | PLA2G1BPLA2G2AALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL6894947 | 0.89 | MAPT (0.41) | HSP90AA1PLA2G2AMAPTALDH1A1TSHR | |
| SCHEMBL6897168 | 0.87 | PLA2G1B (0.44) | HSP90AA1PLA2G1BPLA2G2AMAPTALDH1A1 | |
| SCHEMBL6895052 | 0.87 | PLA2G1B (0.42) | HSP90AA1PLA2G1BPLA2G2AMAPTALDH1A1 | |
| SCHEMBL6888834 | 0.87 | HSP90AA1 (0.41) | HSP90AA1PLA2G1BPLA2G2AMAPTALDH1A1 | |
| SCHEMBL6690226 | 0.87 | PLA2G2A (0.44) | HSP90AA1PLA2G1BPLA2G2AMAPTALDH1A1 | |
| SCHEMBL6896741 | 0.87 | PLA2G2A (0.41) | PLA2G1BPLA2G2AMAPTALDH1A1CYP1A2 | |
| SCHEMBL6894722 | 0.87 | PLA2G2A (0.41) | PLA2G1BPLA2G2AMAPTALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |